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M0627

Sigma-Aldrich

7-Methylguanosine

≥90%

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25 MG
MXP 1,357.00
100 MG
MXP 2,672.00
250 MG
MXP 5,386.00

MXP 1,357.00

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25 MG
MXP 1,357.00
100 MG
MXP 2,672.00
250 MG
MXP 5,386.00

About This Item

Fórmula empírica (notación de Hill):
C11H15N5O5
Número de CAS:
20244-86-4
Peso molecular:
297.27
Beilstein:
3713683
Número MDL:
MFCD16661197
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
24896562
NACRES:
NA.51

MXP 1,357.00

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origen biológico

synthetic

Nivel de calidad

200

Ensayo

≥90%

Formulario

powder

solubilidad

water: 50 mg/mL, clear to hazy, colorless to faintly yellow

temp. de almacenamiento

2-8°C

cadena SMILES

C[n+]1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13

InChI

1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/t4-,6-,7-,10-/m1/s1

Clave InChI

OGHAROSJZRTIOK-KQYNXXCUSA-N

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Descripción general

7-Methylguanosine structure is also referred to as a cap. It is located on the 5′ end of the cytoplasmic mRNA.[1]

Aplicación

7-Methylguanosine has been used in the removal of residual phosphates from pre rigor solution, phosphate mop system and phosphorous standard solution.[2][3][4]

Acciones bioquímicas o fisiológicas

7-Methylguanosine is involved in the processing of a cap-dependent translational process of mRNA. It is also involved in protecting the mRNA from degradation due to ribonucleases and mediate nuclear export. 7-Methylguanosine also permits the recruitment of ribosome.[1]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
WXBF5657V
WXBF3657V
WXBD7979V
WXBF2397V
WXBF0848V

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Vishnu Modur et al.
Nature communications, 9(1), 4410-4410 (2018-10-26)
The nature and role of global transcriptional deregulations in cancers are not fully understood. We report that a large proportion of cancers have widespread defects in mRNA transcription elongation (TE). Cancers with TE defects (TEdeff) display spurious transcription and defective
Jinpeng Gao et al.
Plant physiology, 174(3), 1713-1727 (2017-05-13)
Chilling stress is a major factor limiting plant development and crop productivity. Because the plant response to chilling is so complex, we are far from understanding the genes important in the response to chilling. To identify new genes important in
Esther Z Chen et al.
Investigational new drugs, 32(4), 598-603 (2014-04-09)
Deranged cap-mediated translation is implicated in the genesis, maintenance and progression of many human cancers including mesothelioma. In this study, disrupting the eIF4F complex by antagonizing the eIF4E-mRNA-cap interaction is assessed as a therapy for mesothelioma. Mesothelioma cells were treated
Akiko Ogawa et al.
STAR protocols, 2(4), 100848-100848 (2021-10-09)
About 150 modifications have been identified in RNA species. Besides their regulatory roles in the intracellular gene expression, abundant modified RNA nucleosides are catabolized from RNA and released into extracellular fluids, which can impact extracellular signaling as ligands for receptors.
Nicolas Leulliot et al.
Structure (London, England : 1993), 16(1), 52-61 (2008-01-11)
Loss of N7-methylguanosine (m7G) modification is involved in the recently discovered rapid tRNA degradation pathway. In yeast, this modification is catalyzed by the heterodimeric complex composed of a catalytic subunit Trm8 and a noncatalytic subunit Trm82. We have solved the
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