F2177
Follistatin 288 from mouse
>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
Sinónimos:
FS-288
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25 μG
MXP 14,190.00
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25 μG
MXP 14,190.00
About This Item
Productos recomendados
origen biológico
mouse
Nivel de calidad
recombinante
expressed in baculovirus infected Sf21 cells
Ensayo
>95% (SDS-PAGE)
Formulario
lyophilized powder
potencia
0.04-0.4 mg per mL
mol peso
calculated mol wt ~31 kDa
envase
pkg of 25 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
impurezas
endotoxin, tested
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Fst(14313)
Descripción general
Acciones bioquímicas o fisiológicas
FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders.[1] The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.[3]
High affinity activin-binding protein that can act as an activin antagonist.
Forma física
Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.
Nota de análisis
The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Dam. 1 - Skin Irrit. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Rita Linko et al.
BMC infectious diseases, 14, 253-253 (2014-06-03)
Activin A and its binding protein follistatin (FS) are increased in inflammatory disorders and sepsis. Overexpression of activin A in the lung causes similar histopathological changes as acute respiratory distress syndrome (ARDS). ARDS and severe respiratory failure are complications of
Silvia Näf et al.
PloS one, 9(4), e92175-e92175 (2014-04-26)
The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth. To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women
S Dasgupta et al.
Journal of postgraduate medicine, 58(3), 190-193 (2012-10-02)
Out of a panel of 37 candidate genes tested for linkage with polycystic ovary syndrome (PCOS), the strongest evidence of linkage was reported in the follistatin (FST) gene region. Subsequently, a couple of studies outside India investigated the FST gene
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