This product has not been tested for in vivo use. The material is soluble at 50 mg/mL in 1N HCl. The stock solution would require sterile filtration before further dilution with a sterile buffer or medium.
C6506
4-Chloro-DL-phenylalanine
Sinónimos:
PCP, PCPA
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MXP 3,088.00
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5 G
MXP 3,088.00
25 G
MXP 11,415.00
About This Item
Fórmula lineal:
ClC6H4CH2CH(NH2)CO2H
Número de CAS:
Peso molecular:
199.63
Número CE:
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.32
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Formulario
solid
puntuación de productos alternativos más sostenibles
old score: 2
new score: 1
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características de los productos alternativos más sostenibles
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
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sustainability
Greener Alternative Product
mp
>240 °C (dec.) (lit.)
categoría alternativa más sostenible
temp. de almacenamiento
room temp
cadena SMILES
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
Clave InChI
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Información sobre el gen
human ... TPH1(7166) , TPH2(121278)
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Descripción general
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.
Aplicación
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish[1]
- to induce insomnia in rat models[2]
- used to treat embryos to examine its effect on serotonin[3]
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid[4]
- to feed flies to explore serotonin effect[5]
Acciones bioquímicas o fisiológicas
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.[6]
Tryptophan hydroxylase inhibitor.
Aplicación
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 3 Oral - Skin Sens. 1
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Monier M, et al.
Frontiers in Behavioral Neuroscience, 12(5), 334-334 (2018)
Mariana G Fronza et al.
PloS one, 12(11), e0187445-e0187445 (2017-11-02)
A series of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (SERT) and dopamine transporter (DAT) by docking molecular. 5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1H-1,2,3-triazole-4-carbonitrile (SeTACN) exhibited the best conformation with SERT even higher than fluoxetine and serotonin, suggesting a
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Zheng Y, et al.
PLoS ONE, 10(6), e0130055-e0130055 (2015)
Chromatograms
application for HPLC-
For in vivo experiment, does this have to be dissolved in 1N HCL?
1 answer-
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