C4743

Monoclonal Anti-Cytochrome P450 3A5 antibody produced in mouse

~2 mg/mL, clone F18 P3 B6, purified immunoglobulin, buffered aqueous solution

• Sinónimos: Anti-CP35, Anti-CYP3A5, Anti-P450PCN3, Anti-PCN3
• UNSPSC Code: 12352203

Propiedades

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: F18 P3 B6, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~55 kDa
• species reactivity: human
• concentration: ~2 mg/mL
• technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: 0.5-1.0 μg/mL using human recombinant cytochrome P450 3A5.
• isotype: IgG1
• UniProt accession no.: P20815
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CYP3A5(1577)

Descripción

Specificity

The antibody does not cross react with cytochrome P450 3A4 or 3A7.

Immunogen

synthetic peptide corresponding to amino acids 380-389 of human cytochrome P450 3A5.

Application

Monoclonal Anti-Cytochrome P450 3A5 antibody produced in mouse is suitable for:

• immunohistochemistry
• indirect ELISA
• western blotting at a concentration of 0.5-1.0 μg/mL using human recombinant cytochrome P450 3A5

Biochem/physiol Actions

Cytochrome P450 enzymes are a super family of heme containing mono-oxygenases that in humans are involved with oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. The Cytochrome P450 3A (CYP 3A) family contains several isoforms with the CYP 3A4 isoform contributing most of the family activity and the CYP 3A5, 3A7 and 3A43 being the minor isoforms.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter