CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 5
Synonyms:
CP35, CYPIIIA5, P450PCN3, PCN3
Species:
UniProtKB ID:
Gene ID:
- Human(1577) Summary: This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2010]
- cow(282214) cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
- cow(526682) cytochrome P450, family 3, subfamily A, polypeptide 5
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CYP3A5 (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rat
Application
western blot
Anti-CYP3A5 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
esiRNA
Product Number
Description
Species