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C4428

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

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0.25 unit
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MXP 4,116.00

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Número CAS:
107200-92-0
Número CE:
3.4.21.20 (BRENDA, IUBMB)
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD00130750
Specific activity:
≥60 units/mg protein (Bradford)
Biological source:
human leucocytes

MXP 4,116.00

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biological source

human leucocytes

Quality Segment

200

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

P08311

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Other Notes

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

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Este artículo
C6854C8571SRP6561
Cathepsin G from human leukocytes lyophilized powder, ≥60 units/mg protein (Bradford)

Sigma-Aldrich

C4428

Cathepsin G from human leukocytes

Cathepsin L from human liver ≥0.5 units/mg protein, solution

Sigma-Aldrich

C6854

Cathepsin L from human liver

Cathepsin B from human liver buffered aqueous solution, ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

Sigma-Aldrich

C8571

Cathepsin B from human liver

Cathepsin K Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP6561

Cathepsin K Active human

biological source

human leucocytes

biological source

human liver

biological source

human liver

biological source

human

specific activity

≥60 units/mg protein (Bradford)

specific activity

≥0.5 units/mg protein

specific activity

≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

specific activity

-

Gene Information

human ... CTSG(1511)

Gene Information

human ... CTSL1(1514)

Gene Information

human ... CTSB(1508)

Gene Information

human ... CTSK(1513)

form

lyophilized powder

form

solution

form

buffered aqueous solution

form

liquid

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−70°C

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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