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Merck

A9950

Sigma-Aldrich

Aniracetam

≥98%

Sinónimos:

1-(4-Methoxybenzoyl)-2-pyrrolidinone, Ro 13-5057

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About This Item

Fórmula empírica (notación de Hill):
C12H13NO3
Número de CAS:
Peso molecular:
219.24
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77

En este momento no podemos mostrarle ni los precios ni la disponibilidad

Ensayo

≥98%

emisor

Roche

cadena SMILES

COc1ccc(cc1)C(=O)N2CCCC2=O

InChI

1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3

Clave InChI

ZXNRTKGTQJPIJK-UHFFFAOYSA-N

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Aplicación

Aniracetam has been used in the inhibition screening assays for kinase enzyme.[1]

Acciones bioquímicas o fisiológicas

Aniracetam is a piracetam analog and has low bioavailability due to rapid excretion.[2] It enhances the cognitive thinking and is effective for treatment of sleep and behavioral disorders.[3] Aniracetam is prescribed for anxiety and also enhances learning and memory in situations with induced damage of the brain.[4]
Cognition enhancer (nootropic) that potentiates AMPA receptor mediated ion conductance and potentiates metabotropic glutamate receptor activity.

Características y beneficios

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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Chrysi C Koliaki et al.
CNS neuroscience & therapeutics, 18(4), 302-312 (2011-11-11)
Dementia constitutes an increasingly prevalent cognitive disorder with serious socioeconomic implications. In the present study, we aimed to evaluate the efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors (ChEIs), in terms of several neuropsychological parameters, in a
A Pittaluga et al.
Naunyn-Schmiedeberg's archives of pharmacology, 359(4), 272-279 (1999-05-27)
Aniracetam, 1-(1,3-benzodioxol-5-yl-carbonyl)piperidine (1-BCP) and cyclothiazide, three compounds considered to enhance cognition through modulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors, were evaluated in the 'kynurenate test', a biochemical assay in which some nootropics have been shown to prevent the antagonism by kynurenic
Tatiana Lipina et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32(4), 745-756 (2006-08-29)
In order to test the possible role of mGluR5 signaling in the behavioral endophenotypes of schizophrenia and other psychiatric disorders, we used genetic engineering to create mice carrying null mutations in this gene. Compared to their mGluR5(+/+) littermates, mGluR5(-/-) mice
Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
Tomilov A, et al.
Pharmacological Research, 137(8), 89-103 (2018)
Kazuo Nakamura
CNS drug reviews, 8(1), 70-89 (2002-06-19)
Aniracetam is a pyrrolidinone-type cognition enhancer that has been clinically used in the treatment of behavioral and psychological symptoms of dementia following stroke and in Alzheimer's disease. New discoveries in the behavioral pharmacology, biochemistry and pharmacokinetics of aniracetam provided new

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