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74667

Sigma-Aldrich

Nourseothricin sulfate

≥85% (HPLC)

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About This Item

Número de CAS:
96736-11-7
MDL number:
MFCD00165013
UNSPSC Code:
51102829
NACRES:
NA.85

biological source

Streptomyces noursei

assay

≥85% (HPLC)

form

solid

color

white to light brown

solubility

H2O: soluble 200 mg/mL

suitability

suitable for (selection agent for molecular genetic research work)

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi
mycobacteria
mycoplasma
parasites
viruses
yeast

mode of action

protein synthesis | interferes

storage temp.

2-8°C

General description

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Biochem/physiol Actions

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Packaging

10mg, 100mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Adrian J Verster et al.
G3 (Bethesda, Md.), 7(10), 3337-3347 (2017-08-26)
Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What
Dorota Fennessy et al.
PloS one, 9(5), e97683-e97683 (2014-05-23)
Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci
Mojca Mattiazzi Usaj et al.
Molecular systems biology, 16(2), e9243-e9243 (2020-02-18)
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of
Chetan C Rawal et al.
Cell reports, 31(5), 107603-107603 (2020-05-07)
An important but still enigmatic function of DNA:RNA hybrids is their role in DNA double-strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the human helicase Senataxin, is recruited at an HO endonuclease-induced DSB and
Joan Castells-Ballester et al.
International journal of molecular sciences, 20(24) (2019-12-15)
O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM)
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