PHR1342

Sucralosa

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: 1,6-Dicloro-1,6-didesoxi-β-D-fructofuranosil-4-cloro-4-desoxi-α-D-galactopiranósido, E955, Triclorosacarosa
• Fórmula empírica (notación de Hill): C₁₂H₁₉Cl₃O₈
• Número de CAS: 56038-13-2
• Peso molecular: 397.63
• Beilstein/REAXYS Number: 3654410
• MDL number: MFCD03648615
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823327
• NACRES: NA.24

Propiedades

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to Ph. Eur. Y0001344; traceable to USP 1623626
• API family: sucralose
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl
• InChI: 1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
• InChI key: BAQAVOSOZGMPRM-QBMZZYIRSA-N

Descripción

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Sucralose is a polar, chlorinated sugar synthesized from saccharose precursor. It is widely used as a sweetener in a number of food and beverage products.[1]

Application

Sucralose may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.[2][3][4]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Un saborizante dulce sintético detectable por los humanos. Activa los receptores del sabor dulce T1R2/T1R3 en las células enteroendocrinas y desencadena la secreción hormonal del péptido glucagonoide 1 y el polipéptido gástrico inhibidor, o péptido insulinotrópico dependiente de glucosa.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1094 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable