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Merck

46148

Supelco

Corticosterone

VETRANAL®, analytical standard

Sinónimos:

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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About This Item

Fórmula empírica (notación de Hill):
C21H30O4
Número de CAS:
Peso molecular:
346.46
Beilstein/REAXYS Number:
2339601
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

assay

≥98% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

179-183 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

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General description

Corticosterone is one of the principal steroids secreted by the rat adrenal gland and found in rat plasma.

application

Corticosterone may be used as a reference standard in the determination of corticosterone in plasma samples using high-performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Determination of plasma corticosterone using high-performance liquid chromatography.
Woodward HJC and Emery WP
Journal of Chromatography. B, Biomedical Sciences and Applications, 419(2), 280-284 (1987)
Selective retention of corticosterone by limbic structures in rat brain.
McEwen SB, et al.
Nature, 220(5170), 911-911 (1968)
The estimation of small amounts of corticosterone in rat plasma.
Zenker N and Bernstein ED
The Journal of Biological Chemistry, 231(2), 695-701 (1958)
E N de Haas et al.
Poultry science, 92(9), 2259-2269 (2013-08-21)
Little is known about the relationship between welfare traits and production in laying hen parent stock (PS). In commercial laying hens and pure lines, it is known that aspects associated with reduced welfare such as high fear, stress, and feather
Damiano Azzinnari et al.
Neuropharmacology, 85, 328-341 (2014-06-08)
In neuropsychiatry, animal studies demonstrating causal effects of environmental manipulations relevant to human aetiology on behaviours relevant to human psychopathologies are valuable. Such valid models can improve understanding of aetio-pathophysiology and preclinical discovery and development of new treatments. In depression

Artículos

Milli-Q® ultrapure water systems deliver water free of organic contaminants , including hormones present in a lab's tap water, making it suitable for the most sensitive LC-MS/MS analyses.

Los sistemas de producción de agua ultrapura Milli-Q® suministran agua exenta de contaminantes orgánicos, incluidas las hormonas presentes en el agua del grifo de un laboratorio, lo que los hace adecuados para los análisis mediante LC-MS/MS más sensibles.

Milli-Q® ultrapure water systems deliver water free of organic contaminants , including hormones present in a lab's tap water, making it suitable for the most sensitive LC-MS/MS analyses.

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