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C174

Corticosterone: HBC complex

Name: Corticosterone: HBC complex
Brand: SIGMA
Price: 5144 MXP

≥91.5% (HPLC), free flowing powder, water-soluble stress hormone

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Tamaño de envase	SKU	Disponibilidad	Precio
100 mg		Comprobar disponibilidad del carrito	MXP 5,144.00

Acerca de este artículo

Número CAS:

50-22-6

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD00163376

Assay:

≥91.5% (HPLC)

Form:

free flowing powder

MXP 5,144.00

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Propiedades

Nombre del producto

Corticosterone: HBC complex, free flowing powder

biological source

synthetic (organic)

Quality Segment

100

sterility

non-sterile

assay

≥91.5% (HPLC)

form

free flowing powder

shipped in

ambient

storage temp.

room temp

SMILES string

O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Descripción

Application

Corticosterone: HBC complex has been used:

in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity[1]
to induce acute stress in mice[2]
in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription[3]

Biochem/physiol Actions

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule.[4] Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.[5]

Preparation Note

Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.

Other Notes

Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g

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Este artículo	C2505	H4001	H6635
Sigma-Aldrich C174 Corticosterone: HBC complex	Sigma-Aldrich C2505 Corticosterone	Sigma-Aldrich H4001 Hydrocortisone	Sigma-Aldrich H6635 Hydrocortisone 3-(O-carboxymethyl)oxime
form free flowing powder	form powder	form powder	form powder
assay ≥91.5% (HPLC)	assay ≥92%	assay ≥98% (HPLC)	assay ≥85% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 300	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
shipped in ambient	shipped in ambient	shipped in ambient	shipped in ambient
sterility non-sterile	sterility -	sterility non-sterile	sterility -