672999

V-ATPase Inhibitor, KM91104

• Sinónimos: V-ATPase Inhibitor, KM91104, H+-ATPase Inhibitor
• Fórmula empírica (notación de Hill): C₁₄H₁₂N₂O₄
• Peso molecular: 272.26
• UNSPSC Code: 12352200
• NACRES: NA.28

Propiedades

• assay: >98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC₅₀ of 2.3 µM), in vitro. It is also shown to inhibit osteoclast resorption (IC₅₀ of 1.2 µM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kartner, N., et al. 2010. J. Biol. Chem.285, 37476.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable