565750
γ-Secretase Inhibitor I
The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Sinónimos:
γ-Secretase Inhibitor I, Z-LLNle-CHO
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About This Item
Fórmula empírica (notación de Hill):
C26H41N3O5
Peso molecular:
475.62
UNSPSC Code:
12352200
NACRES:
NA.54
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Quality Level
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
DMSO: 10 mg/mL
50% acetic acid: soluble
shipped in
ambient
storage temp.
−20°C
General description
Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
γ-secretase
γ-secretase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Leu-Leu-Nle-CHO (Nle = Norleucine)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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