407625

STAT3 Inhibitor XVI

The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinónimos: STAT3 Inhibitor XVI, IL-6 Inhibitor
• Fórmula empírica (notación de Hill): C₂₁H₂₂N₂O₃S₃
• Número de CAS: 1260364-43-9
• Peso molecular: 446.61
• Número MDL: MFCD32671868
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: gray
• solubilidad: DMSO: 50 mg/mL, light pink-purple
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(NCC1=CC=CS1)C2=CC(S(N3CCCC3)(=O)=O)=C(C4=CC=C(C)C=C4)S2
• InChI: 1S/C21H22N2O3S3/c1-15-6-8-16(9-7-15)20-19(29(25,26)23-10-2-3-11-23)13-18(28-20)21(24)22-14-17-5-4-12-27-17/h4-9,12-13H,2-3,10-11,14H2,1H3,(H,22,24)
• Clave InChI: NVANVFNPZWSWRM-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC₅₀ = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 &micro:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.

Envase

Packaged under inert gas

Advertencia

Toxicity: Regulatory Review (Z)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Zinzalla, G., et al. 2010. Bioorg Med Chem Lett20, 7029.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable