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878118C

Avanti

C16-02:0 DG

Avanti Research™ - A Croda Brand 878118C

Sinónimos:

1-O-hexadecyl-2-acetyl-sn-glycerol (HAG)

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About This Item

Fórmula empírica (notación de Hill):
C21H42O4
Número de CAS:
77133-35-8
Peso molecular:
358.56
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 5 mL (878118C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 878118C

concentration

1 mg/mL (878118C-5mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC

General description

C16-02:0 DG, also known as 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is an alkylacylglycerol containing primary alcohol group at the C3 position.[1]

Application

C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) may be used to inhibit the formation of 1-O-acyl-NAS.[1]

Biochem/physiol Actions

C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.[2] It exhibits growth inhibitory activity against human promyelocytic leukemia cell line HL-60.[3] HAG acts as a precursor in the biosynthesis of platelet-activating factor via remodeling and retroconversion de novo pathway.[1]

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (878118C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Certificados de análisis (COA)

Lot/Batch Number

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M J McNamara et al.
Biochemical and biophysical research communications, 122(2), 824-830 (1984-07-31)
The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells
Jin Tao et al.
Cellular signalling, 21(9), 1436-1443 (2009-05-15)
Corticotropin-releasing factor (CRF) receptors have been demonstrated to be widely expressed in the central nervous system and in many peripheral tissues of mammalians. However, it is still unknown whether CRF receptors will function in cerebellar Purkinje neurons. In the present
Akira Abe et al.
Journal of lipid research, 48(10), 2255-2263 (2007-07-14)
A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. LPLA2 transfers sn-1 or sn-2 acyl groups of phospholipids to the C1 hydroxyl of the short-chain ceramide N-acetylsphingosine (NAS) under acidic conditions. The
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in

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