860812P

12:0(2S-OH) Ceramide

Avanti Research^™ - A Croda Brand 860812P, powder

• Sinónimos: N-(2′-(S)-hydroxylauroyl)-D-erythro-sphingosine
• Fórmula empírica (notación de Hill): C₃₀H₅₉NO₄
• Número de CAS: 1246298-45-2
• Peso molecular: 497.79
• Número MDL: MFCD22416670
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• Formulario: powder
• envase: pkg of 1 × 5 mg (860812P-5mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand 860812P
• tipo de lípido: sphingolipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCC)=O)CO
• InChI: 1S/C30H59NO4/c1-3-5-7-9-11-13-14-15-16-17-19-20-22-24-28(33)27(26-32)31-30(35)29(34)25-23-21-18-12-10-8-6-4-2/h22,24,27-29,32-34H,3-21,23,25-26H2,1-2H3,(H,31,35)/b24-22+/t27-,28+,29-/m0/s1
• Clave InChI: CPDJNFOAARXMMT-NGXZUFBYSA-N

Descripción

Descripción general

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis.[1] 12:0(2S-OH) Ceramide is a 2S hydroxylated lauric acid-containing ceramide.[2]

Acciones bioquímicas o fisiológicas

Hydroxy fatty acid (hFA)-sphingolipids facilitate cell signaling. hFA-ceramides contribute to the permeability barrier function of the epidermis. Synthesis of hFA-ceramides are catalyzed by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes nervous system disorders leukodystrophy and spastic paraparesis in humans.[3] An antitumor drug, PM02734 requires hFA-ceramides in the cell membrane to exhibit its activity.[4]

Envase

5 mL Amber Glass Screw Cap Vial (860812P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3