The clastogenic potential of 4CMB was assessed in vitro in human lymphocytes from 4 donors (2 male and 2 female) both with and without auxiliary metabolic activation. Although there were some variation in the response of the cells from different
Investigation of the cytogenetic effects of BC and 4CMB on human peripheral lymphocytes in vitro.
At non-inhibitory concentrations, 4CMB and BC both induced small, but dose-related increases in SCE. The dose-response curves gave a highly significant correlation for 4CMB (r = 0.996, P less than 0.001) and a significant correlation for BC (r = 0.757
The assay of 4-chloromethylbiphenyl in the dominant lethal assay in mice.
The study was part of the UK EMS Genetic Toxicology trial, to determine the clastogenic potential of 4CMB in the bone-marrow cell chromosomes of the Chinese hamster. At dose levels of 50, 100, 200, 300 and 400 mg/kg of 4CMB
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