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920444

Sigma-Aldrich

mPEG functionalized gelatin

50% PEGylation, PEG average Mn 1k, gel strength 300 g Bloom

Sinónimos:

PEGylated Gelatin

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About This Item

Fórmula lineal:
(C32H50N9O12-)m(CH2CH2O)n
UNSPSC Code:
12352201
NACRES:
NA.23

Quality Level

100

form

(solid or chunk(s) or fiber)

mol wt

PEG average Mn 1k

color

white to off-white

storage temp.

2-8°C

Categorías relacionadas

Application

mPEG functionalized gelatin is Type A gelatin grafted with PEG that can be used in drug delivery research. Gelatin is a denatured protein that is obtained by hydrolysis of animal collagen. Its biodegradability, biocompatibility, chemical modification potential and cross-linking possibility make gelatin-based nanoparticles (GNPs) a promising carrier system for drug delivery applications. mPEG functionalization has several advantages − prolonged circulation in the body, decreased degradation by metabolic enzymes, and reduction or elimination of protein immunogencity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Modified gelatin nanoparticles for gene delivery.
Wettig S D, et al.
Int. J. Pharmacol., 554, 224-234 (2019)
Ahmed O Elzoghby
Journal of controlled release : official journal of the Controlled Release Society, 172(3), 1075-1091 (2013-10-08)
Gelatin is one of the most versatile natural biopolymers widely used in pharmaceutical industries due to its biocompatibility, biodegradability, low cost and numerous available active groups for attaching targeting molecules. These advantages led to its application in the synthesis of
Sajed Amjadi et al.
Materials science & engineering. C, Materials for biological applications, 97, 833-841 (2019-01-27)
Betanin (BET) can reduce the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues in co-administration with them because of the synergistic therapeutic effect and consequently the reduced required amount of anticancer agents. Despite interest in
A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy.
Ghorbani M, et al.
Materials Science and Engineering, C, 97, 833-841 (2019)

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