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725668

Sigma-Aldrich

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated

average Mn 2,000

Sinónimos:

NIPAM polymer, PNIPAM-NHS, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM

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About This Item

Fórmula lineal:
(C6H11NO)n SCH2CH2COO(C4H4NO2)
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder

mol wt

average Mn 2,000

mp

>300 °C

Categorías relacionadas

Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Novel polymer for development of thermosensitive coated micro/nano materialincluding thermoresponsive polymeric drug delivery systems. The NHS ester functional group can be used to conjugate a variety of biomolecules such as enzymes† to the polymer chain.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Acrylate-PEG2K-NHS average Mn 2,000

Sigma-Aldrich

JKA5021

Acrylate-PEG2K-NHS

Rzaev, Z.M.O.; Dincer, S.; Piskin, E.
Progress in Polymer Science, 32, 534-534 (2007)
K Fujimoto et al.
Biomacromolecules, 1(4), 515-518 (2001-11-17)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a
Chung, J. E.; Yokoyama, M.; Suzuki, K.; Aoyagi, T.; Sakurai, Y.; Okano, T.
Colloids and Surfaces, B: Biointerfaces, 9, 37-37 (1997)
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in

Artículos

Designing Temperature and pH Sensitive NIPAM Based Polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

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