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414840

Sigma-Aldrich

4-Nitro-3-pyrazolecarboxylic acid

98%

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About This Item

Fórmula empírica (notación de Hill):
C4H3N3O4
Número de CAS:
5334-40-7
Peso molecular:
157.08
MDL number:
MFCD00090899
UNSPSC Code:
12352100
PubChem Substance ID:
24865960
NACRES:
NA.22

assay

98%

mp

223-225 °C (dec.) (lit.)

SMILES string

OC(=O)c1n[nH]cc1[N+]([O-])=O

InChI

1S/C4H3N3O4/c8-4(9)3-2(7(10)11)1-5-6-3/h1H,(H,5,6)(H,8,9)

InChI key

ZMAXXOYJWZZQBK-UHFFFAOYSA-N

General description

4-Nitro-3-pyrazolecarboxylic acid is a pyrazole derivative. Catalytic activity of bimetallic colloids, composed of silver nanoparticles partially coated with Pd clusters, adsorbed on 4-nitro-3-pyrazolecarboxylic acid, has been investigated by Surface-enhanced Raman scattering (SERS) spectroscopy. Effects of this pyrrazole on blood flow and its palladium hydrogenation has been studied.

Application

4-Nitro-3-pyrazolecarboxylic acid may be used as a starting reagent for the synthesis of library of pyrazole derivatives, potential A3 adenosine receptor (A3AR) antagonists.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jing Wei et al.
Neurochemistry international, 55(7), 637-642 (2009-06-23)
Adenosine is known to act as a neuromodulator by suppressing synaptic transmission in the central and peripheral nervous system. A(3) adenosine receptor (A(3)AR) antagonists were recently considered as potential drugs for the treatment of cardiac ischemia and inflammation diseases. To
Bo Xuan et al.
Acta pharmacologica Sinica, 23(8), 705-712 (2002-07-31)
Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemia have been studied. The compounds were tested on ocular blood flow of ocular hypertensive (40 mmHg) rabbit eyes with colored microsphere technique. They were also
SERS investigation on 4-nitro-3-pyrazolecarboxylic acid adsorbed on palladium-doped silver nanoparticles.
Pergolese B, et al.
Vibrational Spectroscopy, 48(1), 107-112 (2008)
Hydrogenation on Granular Palladium-containing Catalysts: II. Hydrogenation of Nitroheterocyclic Compounds
Russ. J. Org. Chem., 38, 269-271 (2002)

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