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SML0698

Sigma-Aldrich

CID 11210285 hydrochloride

≥98% (HPLC)

Synonym(s):

2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine hydrochloride, AMBMP, N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride, Wnt Agonist

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5 MG
MXP 2,483.00
25 MG
MXP 12,713.00

MXP 2,483.00

Estimated to ship onApril 12, 2025

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5 MG
MXP 2,483.00
25 MG
MXP 12,713.00

About This Item

Empirical Formula (Hill Notation):
C19H18N4O3 · HCl
CAS Number:
853220-52-7
Molecular Weight:
386.83
UNSPSC Code:
12352200
NACRES:
NA.77

MXP 2,483.00

Estimated to ship onApril 12, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(Cc3cc4c(cc3)OCO4)c1nc(nc(c1)c2cc(ccc2)OC)N

InChI

1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

InChI key

FABQUVYDAXWUQP-UHFFFAOYSA-N

Application

CID 11210285 hydrochloride has been used as a Wnt agonist.[1]

Biochem/physiol Actions

CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β.
CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β. CID 11210285is a Wnt agonist.

Other Notes

Light sensitve and air sensitive.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
046M4711V
104M4751V
053M4713V

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The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.
Cosin-Roger J, et al.
Mucosal Immunology, 9(4), 986-986 (2016)
Amalia Rosner et al.
Developmental biology, 448(2), 320-341 (2018-11-06)
Inhibitors of Apoptosis Protein (IAP) genes participate in processes like apoptosis, proliferation, innate immunity, inflammation, cell motility, differentiation and in malignancies. Here we reveal 25 IAP genes in the tunicate Botryllus schlosseri's genome and their functions in two developmental biology

Questions

  1. What other vehicles can be used for the administration of the agonist in a mouse model? It can be administered locally (bone tissue) or only systemically?

    1 answer

    1. This product has not been tested for in vivo or in vitro applications. The method of administration will need to be validated by the end user. It may be helpful to view peer-reviewed articles. Please see the two publications below :

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662016/
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565963/

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