The 50mg pack size is packaged in a 20mL amber glass bottle.
S0130
Streptozocin
Streptozocin
≥75% α-anomer basis,≥98% (HPLC), powder, DNA alkylating agent
Synonym(s):
STZ, Streptozotocine, N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin
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50 MG
MXP 1,269.00
100 MG
MXP 2,045.00
500 MG
MXP 5,471.00
1 G
MXP 9,413.00
5 G
MXP 41,173.00
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50 MG
MXP 1,269.00
100 MG
MXP 2,045.00
500 MG
MXP 5,471.00
1 G
MXP 9,413.00
5 G
MXP 41,173.00
About This Item
Empirical Formula (Hill Notation):
C8H15N3O7
CAS Number:
Molecular Weight:
265.22
Beilstein:
2060675
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Streptozocin, ≥75% α-anomer basis, ≥98% (HPLC), powder
Quality Level
Assay
≥75% α-anomer basis
≥98% (HPLC)
form
powder
color
white to light yellow
mp
121 °C (dec.) (lit.)
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
storage temp.
−20°C
SMILES string
CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
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General description
Streptozocin (STZ) is an antineoplastic antibiotic. This N-nitroso-containing compound acts as a nitric oxide donor in pancreatic islets. It is a methylnitrosourea attached to a single molecule of glucosamine and has a high affinity for the cell surface glucose transporter glucose transporter type 2 (GLUT2), which is highly expressed on beta cells of the islets of Langerhans.[1] Streptozotocin cannot pass through the blood-brain barrier, but its metabolites are usually seen in the cerebrospinal fluid.
In cell culture medium, it has been shown to have a biological half-life of approximately 19 minutes. It is a strong methylating agent that interacts with DNA in vitro to produce methylated purines. It can impact glucose metabolism because STZ is particularly toxic to the insulin-producing beta cells of the pancreas in mammals and is also an effective antibiotic against Gram-negative bacteria. It inhibits the synthesis of DNA in microorganisms and mammalian cells by alkylation and cross-linking the strands of DNA and affects all stages of the mammalian cell cycle. STZ is considered mutagenic, carcinogenic, and possibly teratogenic in humans.[2] It is cytotoxic to the neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
In cell culture medium, it has been shown to have a biological half-life of approximately 19 minutes. It is a strong methylating agent that interacts with DNA in vitro to produce methylated purines. It can impact glucose metabolism because STZ is particularly toxic to the insulin-producing beta cells of the pancreas in mammals and is also an effective antibiotic against Gram-negative bacteria. It inhibits the synthesis of DNA in microorganisms and mammalian cells by alkylation and cross-linking the strands of DNA and affects all stages of the mammalian cell cycle. STZ is considered mutagenic, carcinogenic, and possibly teratogenic in humans.[2] It is cytotoxic to the neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Application
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Other Notes
Mixed anomers
also commonly purchased with this product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 2 - Flam. Sol. 1 - Muta. 2
Storage Class Code
4.1B - Flammable solid hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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diabetes studies and muscle hypertrophy models?
Marco
Analytical Biochemistry, 504, 38-40 (2016)
Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice
Sung-Hsun Yu
PLoS ONE (2016)
Streptozotocin
Abdollahi, M and Hosseini, A
Encyclopedia of Toxicology (2014)
Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans
Chinedum
Journal of diabetes and metabolic disorders, 12, 60-60 (2013)
Streptozotocin
Abdollahi, M and Hosseini, A
Encyclopedia of Toxicology (2014)
Articles
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
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What's the bottle size for Streptozotocin 50mg
1 answer-
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Can Streptozotocin be transported at ambient temperature, without losing his integrity?
1 answer-
This product is shipped on dry ice and may degrade if exposed to ambient temperatures for extended periods. The product is stable when stored frozen and protected from moisture and air.
To further discuss shipping temperature of this material Please navigate to the link https://www.sigmaaldrich.com/support/customer-support, click on "Products Pricing & Availability" under the Products Section with all the required information so that a member of the Customer Service team can reach out to assist further. Thank you.
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Can Product S0130, Streptozocin, be used to induce diabetes? What concentration should be used?
1 answer-
We do not test Streptozocin, Product No. S0130 for biological activity. We recommend screening lots for biological activity. An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).
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How should I store Product S0130, Streptozocin, upon receipt?
1 answer-
Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How do I store solutions of Product S0130, Streptozocin?
1 answer-
Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.
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How can I make a solution of Product S0130, Streptozocin?
1 answer-
This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.
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What is the half-life of Product S0130, Streptozocin?
1 answer-
Streptozocin has a reported half life of 15 to 30 minutes.
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