04-299
Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3
clone 10C3, Upstate®, from mouse
Synonym(s):
INSR
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
10C3, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pTyr1150/pTyr1151)
Gene Information
human ... INSR(3643)
Specificity
Recognizes phosphorylated domain of Insulin receptor on Tyrosine 1150/1151.
Immunogen
KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyrosine 1150/1151 on phosphorylated insulin receptor.
Application
Detect phospho-Insulin Receptor (Tyr 1150/1151) using this Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3 validated for use in EA & WB.
Quality
Routinely evaluated by immunoblot.
Target description
97 kDa
Physical form
Format: Purified
In 1 mL of PBS containing 0.09% sodium azide, PEG, and sucrose and 50% glycerol.
Analysis Note
Control
Includes pervanadate treated HEK293 lysate as a positive control
Includes pervanadate treated HEK293 lysate as a positive control
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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Natalie N Rizk et al.
Fertility and sterility, 86(4 Suppl), 1217-1222 (2006-09-12)
To determine whether the insulin receptor (IR), insulin-like growth factor-I receptor (IGF-IR), and IGF-I are expressed differentially in fibroblasts isolated from normal peritoneal and adhesion tissue before and after 24-hour treatment with increasing glucose concentrations. Prospective experimental study. University medical
Qiu-yan Wang et al.
The FEBS journal, 274(2), 526-538 (2007-01-19)
Two H7721 human hepatocarcinoma cell lines showing moderate and high expression of alpha1,3-fucosyltransferase (FucT)-VII cDNA were established and designated FucTVII-M and FucTVII-H, respectively. In alpha1,3-FucT-VII-transfected cells, expression of insulin receptor (InR) alpha- and beta subunits and epidermal growth factor receptor
Rita Slaaby et al.
The Journal of biological chemistry, 281(36), 25869-25874 (2006-07-13)
Insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) are both from the same subgroup of receptor tyrosine kinases that exist as covalently bound receptor dimers at the cell surface. For both IR and IGF-IR, the most described forms
Atsumi Tsuji-Hosokawa et al.
Pediatric diabetes, 18(8), 917-924 (2017-02-10)
Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality
Adrián Martín-Segura et al.
Aging cell, 18(3), e12932-e12932 (2019-03-19)
In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of
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