G002

Isoguvacine hydrochloride

solid

• Synonym(s): 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
• Empirical Formula (Hill Notation): C₆H₉NO₂ · HCl
• CAS Number: 68547-97-7
• Molecular Weight: 163.60
• MDL number: MFCD00055192
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278160
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 200
• color: white
• solubility: H₂O: soluble (refrigerate if not used immediately.); methanol: slightly soluble; neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)
• SMILES string: Cl[H].OC(=O)C1=CCNCC1
• InChI: 1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
• InChI key: SUWREQRNTXCCBL-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Description

Application

Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABA_A) receptor agonist:

• to study its effects on neuronal activity in rats
• to study its antiallodynic effect in rats
• to study its effects on baroreflex gains in rats

Biochem/physiol Actions

Isoguvacine is a strong γ-aminobutyric acid A (GABA_A) receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves