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Key Documents

B0490000

Benzarone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone, NSC 82134

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About This Item

Empirical Formula (Hill Notation):
C17H14O3
CAS Number:
Molecular Weight:
266.29
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

benzarone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

InChI key

RFRXIWQYSOIBDI-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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High-performance liquid chromatographic determination of benzbromarone and the main metabolite benzarone in serum.
H Vergin et al.
Journal of chromatography, 183(3), 383-386 (1980-09-12)
S G Wood et al.
Xenobiotica; the fate of foreign compounds in biological systems, 17(7), 881-896 (1987-07-01)
1. The metabolic fate of 14C-benzarone in the rat and dog has been compared to that in human subjects. An oral dose was well-absorbed in all three species. However, the 14C excretion patterns differed: humans (100 mg) excreted means of
[Drug modification of a risk factor of thrombosis in patients with varicosis].
S Haas et al.
Fortschritte der Medizin, 100(30), 1418-1422 (1982-08-12)
W Voelter et al.
Journal of chromatography, 290, 1-12 (1984-05-04)
Using 2-ethyl-3-(4- hydroxybenzoyl )benzofuran ( EHBB ) as an example, biotransformation in rabbits and rats and by rat hepatocyte suspensions was studied by high-performance liquid chromatography (HPLC) and mass spectrometry. The biotransformation of N-alkyl-substituted piperidines by rat hepatocytes gives valuable
A Schmidt et al.
Arzneimittel-Forschung, 32(8), 810-815 (1982-01-01)
Rats of BD X strain and SHR/NIH Montreal Ingelheim strain (genetic hypertension) received a diet containing 3.9% cholesterol or 3.7% cholesterol plus 0.6% benzarone, respectively, and libitum for 5 or 9 months. The following chemical and ultrastructural results were obtained.

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