B0490000
Benzarone
European Pharmacopoeia (EP) Reference Standard
Synonym(s):
(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone, NSC 82134
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About This Item
Recommended Products
grade
pharmaceutical primary standard
API family
benzarone
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
InChI
1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3
InChI key
RFRXIWQYSOIBDI-UHFFFAOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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High-performance liquid chromatographic determination of benzbromarone and the main metabolite benzarone in serum.
Journal of chromatography, 183(3), 383-386 (1980-09-12)
Xenobiotica; the fate of foreign compounds in biological systems, 17(7), 881-896 (1987-07-01)
1. The metabolic fate of 14C-benzarone in the rat and dog has been compared to that in human subjects. An oral dose was well-absorbed in all three species. However, the 14C excretion patterns differed: humans (100 mg) excreted means of
[Drug modification of a risk factor of thrombosis in patients with varicosis].
Fortschritte der Medizin, 100(30), 1418-1422 (1982-08-12)
Journal of chromatography, 290, 1-12 (1984-05-04)
Using 2-ethyl-3-(4- hydroxybenzoyl )benzofuran ( EHBB ) as an example, biotransformation in rabbits and rats and by rat hepatocyte suspensions was studied by high-performance liquid chromatography (HPLC) and mass spectrometry. The biotransformation of N-alkyl-substituted piperidines by rat hepatocytes gives valuable
Arzneimittel-Forschung, 32(8), 810-815 (1982-01-01)
Rats of BD X strain and SHR/NIH Montreal Ingelheim strain (genetic hypertension) received a diet containing 3.9% cholesterol or 3.7% cholesterol plus 0.6% benzarone, respectively, and libitum for 5 or 9 months. The following chemical and ultrastructural results were obtained.
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