07386
Coenzyme Q10
analytical standard
Synonym(s):
Q-10, Ubiquinone 50, Ubiquinone-10
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About This Item
Empirical Formula (Hill Notation):
C59H90O4
CAS Number:
Molecular Weight:
863.34
Beilstein:
1900141
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
analytical standard
Quality Level
Assay
≥97.5% (HPLC)
form
powder
shelf life
limited shelf life, expiry date on the label
impurities
≤1.0% water
color
faint yellow to dark orange
mp
49 °C
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
storage temp.
−20°C
SMILES string
O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O
InChI
1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChI key
ACTIUHUUMQJHFO-UPTCCGCDSA-N
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General description
Coenzyme Q10 is the central electron carrier in mitochondrial respiratory chain, originating from food intake as well as from endogenous synthesis. It commonly acts in its reduced form to prevent lipid peroxidation in biological membranes and in serum low-density lipoproteins (LDL). It also tends to protect the mitochondrial membrane proteins and DNA against oxidative damage along with lipid peroxidation.
Application
- Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice: Research demonstrates Coenzyme Q10′s effectiveness in reducing cardiac damage through antioxidant mechanisms and inflammation modulation, offering insights for potential human therapeutic applications (Antar et al., 2024).
- Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10: This study explores how Coenzyme Q10, along with taurine, can mitigate the negative hematological effects of chlorpromazine, suggesting its use in managing side effects in psychiatric treatments (Obukohwo et al., 2024).
- Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms: Discusses the role of Coenzyme Q10 in muscle health, particularly in preventing atrophy through mitochondrial support and enhancing cellular energy metabolism, pertinent for sports medicine and aging (Shen et al., 2024).
- Identification of a family of species-selective complex I inhibitors as potential anthelmintics: Although indirectly related, this study hints at the role of mitochondrial function, which could be linked to Coenzyme Q10′s effects in similar pathways, suggesting a novel application area in parasitology and infectious diseases (Davie et al., 2024).
Caution
light sensitive
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also commonly purchased with this product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults
Niklowitz P, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 342(1-2), 219-226 (2004)
Igor Pravst et al.
Critical reviews in food science and nutrition, 50(4), 269-280 (2010-03-20)
Coenzyme Q10 (CoQ(10)) is an effective natural antioxidant with a fundamental role in cellular bioenergetics and numerous known health benefits. Reports of its natural occurrence in various food items are comprehensively reviewed and critically evaluated. Meat, fish, nuts, and some
Marcia Wyman et al.
Cleveland Clinic journal of medicine, 77(7), 435-442 (2010-07-06)
Some small clinical trials seem to show that coenzyme Q10 supplements can be used to lower blood pressure and to treat or prevent myalgia caused by hydroxymethylglutaryl coenzyme A reductase inhibitors (statins). However, larger trials are needed to determine if
Marnie Potgieter et al.
Nutrition reviews, 71(3), 180-188 (2013-03-05)
Coenzyme Q10 (CoQ10) is the only lipid-soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration.
Adarsh Kumar et al.
Pharmacology & therapeutics, 124(3), 259-268 (2009-07-30)
Coenzyme Q10 (ubiquinone) is a mitochondrial coenzyme which is essential for the production of ATP. Being at the core of cellular energy processes it assumes importance in cells with high energy requirements like the cardiac cells which are extremely sensitive
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