PHL89220

α-常春藤素

phyproof^® Reference Substance

• 别名: (3β,4α)-3-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid
• 经验公式（希尔记法）: C₄₁H₆₆O₁₂
• CAS号: 27013-91-8
• 分子量: 750.96
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: primary reference standard
• 產品線: phyproof^® Reference Substance
• 化驗: ≥95.0% (HPLC)
• 形狀: solid
• 製造商／商標名: PhytoLab
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)CO[C@H]2O[C@H]3CC[C@@]4(C)[C@@H](CC[C@]5(C)[C@@H]4CC=C6[C@@H]7CC(C)(C)CC[C@@]7(CC[C@@]56C)C(O)=O)[C@]3(C)CO)[C@H](O)[C@H](O)[C@H]1O
• InChI: 1S/C41H66O12/c1-21-28(44)30(46)31(47)33(51-21)53-32-29(45)24(43)19-50-34(32)52-27-11-12-37(4)25(38(27,5)20-42)10-13-40(7)26(37)9-8-22-23-18-36(2,3)14-16-41(23,35(48)49)17-15-39(22,40)6/h8,21,23-34,42-47H,9-20H2,1-7H3,(H,48,49)/t21-,23-,24-,25+,26+,27-,28-,29-,30+,31+,32+,33-,34-,37-,38-,39+,40+,41-/m0/s1
• InChI 密鑰: KEOITPILCOILGM-LLJOFIFVSA-N

说明

一般說明

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

應用

• α-Hederin as a potent inhibitor in cancer research: α-Hederin has been identified and validated as a potent inhibitor of the Wnt/β-catenin signaling pathway in breast cancer stem cells, offering a promising avenue for targeted cancer therapy and highlighting its role in anti-cancer pharmacological research (Saliu et al., 2024).
• α-Hederin in overcoming drug resistance: This natural triterpenoid saponin has shown efficacy in reprogramming miRNA activity to overcome paclitaxel resistance mediated by small extracellular vesicles in non-small cell lung cancer (NSCLC), reinforcing its potential as a valuable agent in respiratory research and cancer treatment (Chang et al., 2024).
• α-Hederin′s role in promoting ferroptosis in cancer: Research indicates that α-Hederin can induce ferroptosis and reverse chemoresistance to cisplatin in non-small cell lung cancer, providing insights into its mechanism as a cytotoxic agent and its applications in enhancing the efficacy of conventional chemotherapies (Han et al., 2024).
• Molecular mechanisms of α-Hederin in tumor progression: A review of the molecular mechanisms by which α-Hederin influences tumor progression highlights its potential uses in biochemistry and pharmaceutical research, particularly for its anti-inflammatory and anticancer properties (Meng et al., 2024).

其他說明

This compound is commonly found in plants of the genus: hedera

法律資訊

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable