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Merck
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文件

V0882

Sigma-Aldrich

D-Val-Leu-Lys 4-硝基苯胺 二盐酸盐

plasmin substrate

别名:

D-Val-Leu-Lys-pNA 二盐酸盐, D-缬氨酰-L-亮氨酰-L-赖氨酸 4-硝基苯胺 二盐酸盐

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About This Item

经验公式（希尔记法）:
C23H38N6O5 · 2HCl
CAS号:
62354-43-2
分子量:
551.51
MDL號碼:
MFCD00077899
分類程式碼代碼:
12352204
PubChem物質ID:
24900701
NACRES:
NA.32

化驗

≥98% (TLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless to yellow

儲存溫度

−20°C

SMILES 字串

Cl.Cl.CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C23H38N6O5.2ClH/c1-14(2)13-19(28-23(32)20(25)15(3)4)22(31)27-18(7-5-6-12-24)21(30)26-16-8-10-17(11-9-16)29(33)34;;/h8-11,14-15,18-20H,5-7,12-13,24-25H2,1-4H3,(H,26,30)(H,27,31)(H,28,32);2*1H/t18-,19-,20+;;/m0../s1

InChI 密鑰

VESQMNNSPPEOSZ-ZLARAOTRSA-N

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應用

D-Val-Leu-Lys 4-硝基苯胺二盐酸盐已被用作发色底物，以在酰胺分解活性测定和纤溶酶原活化测定中确定由纤溶酶原形成的纤溶酶。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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D -Val-Leu-Arg 对硝基苯胺 二乙酸盐 ≥95% (HPLC)

Sigma-Aldrich

V6258

D -Val-Leu-Arg 对硝基苯胺 二乙酸盐

S Ueshima et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 7(5), 522-529 (1996-07-01)
Staphylokinase (SAK), produced by Staphylococcus aureus, induces fibrinolytic activity in circulation without systemic fibrinolytic activation. Since the effect of blood vessels on the activity of SAK has not yet been clarified, plasminogen activator (PA) activity of SAK in the presence
Sahin Sultana et al.
Immunology letters, 209, 53-66 (2019-03-30)
uPA/tPA-mediated activation of plasminogen/plasmin pathway during S. aureus arthritis facilitates the invasion of phagocytes in the affected joint, induces production of cytokines and triggers inflammatory pathways. PAI-1, an effective inhibitor of both uPA and tPA, attenuates plasmin activity. Hence, the
L C Petersen
European journal of biochemistry, 245(2), 316-323 (1997-04-15)
The two zymogens, plasminogen and pro-urokinase plasminogen activator (pro-uPA), constitute a system of reciprocal activation, since plasmin, generated by uPA-catalysed plasminogen activation, can activate pro-uPA to uPA. Two such zymogens, when mixed, will undergo autocatalytic, reciprocal activation resulting in generation
Genetic modification of the streptokinase gene to study the interaction of streptokinase with plasminogen.
S Lizano et al.
Developments in biological standardization, 85, 195-198 (1995-01-01)
K M Rippel et al.
Journal of dairy science, 87(8), 2344-2350 (2004-08-26)
The plasmin system native to bovine milk consists of the caseinolytic serine proteinase plasmin; its inactive zymogen, plasminogen; plasminogen activators; and inhibitors. Evidence in the literature indicates that whey proteins may inhibit plasmin activity, but there is very little mention
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实验方案

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Protocol for Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

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