U8881
UCL 1684 ditrifluoroacetate hydrate
别名:
6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
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所有图片(1)
About This Item
线性分子式:
(C34H30N4)2+ · (C2F3O2-)2 · xH2O
CAS号:
分子量:
720.66 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
顏色
white to off-white
溶解度
DMSO: 10 mg/mL
SMILES 字串
[H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
InChI
1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
InChI 密鑰
YROHEYZVNZITJN-DDVHGCDCSA-N
應用
UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries.
生化／生理作用
UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.
特點和優勢
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
準備報告
UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
P M Dunn
European journal of pharmacology, 368(1), 119-123 (1999-03-30)
The novel K+ channel blocker 6,10-diaza-3(1,3)8,(1,4)-dibenzena-1,5(1,4)-diquinolinacy clodecaphane (UCL 1684) has been tested for its ability to inhibit Ca2+ -activated K+ currents in cultured rat chromaffin cells. Low nanomolar concentrations of UCL 1684 produced a rapid and reversible inhibition of the
Chao Fan Liang et al.
The Journal of pharmacology and experimental therapeutics, 334(1), 223-231 (2010-03-25)
The present experiments investigated whether endothelium-derived mediators modulate the effect of natriuretic peptides in porcine coronary arteries. Rings with and without endothelium were suspended in organ chambers for isometric tension recording. Concentration-relaxation curves to C-type natriuretic peptide (CNP) and atrial
Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels
Weatherall KL, et al.
Proceedings of the National Academy of Sciences of the USA, 108(45), 18494-18499 (2011)
Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion
Zhang M, et al.
The Journal of General Physiology, 126(4), 353-363 (2005)
UCL 1684: a potent blocker of Ca2+-activated K+ channels in rat adrenal chromaffin cells in culture
Dunn PM
European Journal of Pharmacology, 368(1), 119-123 (1999)
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