所有图片(1)
About This Item
经验公式（希尔记法）:
C22H17ClN2
CAS号:
分子量:
344.84
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
off-white
溶解度
DMSO: 2 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChI 密鑰
KBFUQFVFYYBHBT-UHFFFAOYSA-N
應用
TRAM-34 已被用于研究其对预防球囊血管成形术后血管再狭窄的作用。
生化／生理作用
TRAM-34 对 IK Ca 1 通道的选择性是其他 K + 通道的 100 倍 (K d = 20 nM)（卡律蝎毒素，K d = 5 nM, 克霉唑，K d = 70 nM；尼群地平 K d = 900 nM）。此外，已知 TRAM-34 可抑制人 T 淋巴细胞的活化 。
TRAM-34 是中电导 Ca2+ 激活 K+ 通道的强效抑制剂。
準備報告
TRAM-34 可溶于 DMSO (2 mg/mL)。但不溶于水。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 4
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
Zhihua Yu et al.
Frontiers in cellular neuroscience, 11, 319-319 (2017-10-28)
Ischemic stroke is a devastating neurological disease that can initiate a phenotype switch in astrocytes. Reactive astrogliosis is a significant pathological feature of ischemic stroke and is accompanied by changes in gene expression, hypertrophied processes and proliferation. The intermediate-conductance Ca
K George Chandy et al.
Trends in pharmacological sciences, 25(5), 280-289 (2004-05-04)
The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from the resting to
Crocin Improves the Endothelial Function Regulated by Kca3.1 Through ERK and Akt Signaling Pathways.
Huike Yang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(2), 765-780 (2018-04-06)
Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function through activating the eNOS(endothelial nitric oxide synthase) /NO pathway and/or the intermediate-conductance Ca2+-activated K+ channels (KCa3.1). In this study, rat aortic rings
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