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U101

Sigma-Aldrich

5-Methylurapidil

solid

别名:

5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]­propyl]­amino]-1,3-dimethyluracil

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About This Item

经验公式（希尔记法）:
C21H31N5O3
CAS号:
34661-85-3
分子量:
401.50
MDL號碼:
MFCD00078602
分類程式碼代碼:
12352200
PubChem物質ID:
24277800
NACRES:
NA.77

形狀

solid

品質等級

100

顏色

white

溶解度

H2O: 0.4 mg/mL
0.1 M HCl: 3.8 mg/mL

SMILES 字串

Cl[H].COc1ccccc1N2CCN(CCCNC3=C(C)C(=O)N(C)C(=O)N3C)CC2

InChI

1S/C21H31N5O3.ClH/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4;/h5-6,8-9,22H,7,10-15H2,1-4H3;1H

InChI 密鑰

WAZDYFHTLYHMKO-UHFFFAOYSA-N

基因資訊

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

應用

5-Methylurapidil has been used for competitive binding in radioligand binding assays.

生化／生理作用

Selective α1A-adrenoceptor antagonist; antihypertensive.

特點和優勢

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

5-Methylurapidil is soluble in water at 0.4 mg/ml and is also soluble in 0.1 M HCl at 3.8 mg/ml.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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M Endoh et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(5), 578-585 (1992-05-01)
In order to elucidate the contribution of alpha 1A subtype to the positive inotropic effect mediated by myocardial alpha 1 adrenoceptors, the influence of the alpha 1A selective antagonists WB 4101 and 5-methylurapidil on the alpha 1-mediated positive inotropic effect
Caroline Putzke et al.
Cardiovascular research, 75(1), 59-68 (2007-03-29)
The outward current flowing through the two-pore domain acid-sensitive potassium channel TASK-1 (I(TASK)) and its inhibition via alpha1-adrenergic receptors was studied in rat ventricular cardiomyocytes. Quantitative RT-PCR experiments were carried out with mRNA from rat heart. Patch-clamp recordings were performed
Rocío Alcántara-Hernández et al.
Biochimica et biophysica acta, 1864(12), 2378-2388 (2017-09-11)
In LNCaP cells that stably express α
Abdul H Khan et al.
European journal of pharmacology, 569(1-2), 110-118 (2007-06-15)
This study investigated whether the alpha(1)-adrenoceptor subtype(s) mediating the vasoconstrictor actions of the renal sympathetic nerves were altered in rats with cisplatin-induced renal failure. Male Wistar Kyoto rats were used and half received cisplatin (5 mg/kg i.p.) to induce renal
Wesley B Asher et al.
Journal of chemical information and modeling, 47(5), 1906-1912 (2007-08-25)
In this study, we have developed a two model system to mimic the active and inactive states of a G-protein coupled receptor specifically the alpha1A adrenergic receptor. We have docked two agonists, epinephrine (phenylamine type) and oxymetazoline (imidazoline type), as
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