所有图片(2)
About This Item
经验公式（希尔记法）:
C10H6N2O2
CAS号:
分子量:
186.17
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic (organic)
质量水平
方案
≥98%
表单
powder
效能
35 μM IC50
溶解性
DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
储存温度
2-8°C
SMILES字符串
Oc1ccc(cc1O)\C=C(\C#N)C#N
InChI
1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
InChI key
VTJXFTPMFYAJJU-UHFFFAOYSA-N
基因信息
human ... CDK2(1017)
应用
Tyrphostin 23可作为酪氨酸激酶抑制剂用于研究大鼠ghrelin诱导的GH3细胞MAPK激活。Tyrphostin 23也被用作分析其对神经磷酸酶（SN）诱导的中性粒细胞趋化的作用。
生化/生理作用
Tyrphostin 23是表皮生长因子（EGF）受体激酶功能的小分子抑制剂。该分子与蛋白酪氨酸激酶（PTK）结构域的底物亚位点结合。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
其他客户在看
Mikyung Yang et al.
American journal of physiology. Lung cellular and molecular physiology, 294(5), L1007-L1012 (2008-03-18)
We assessed the roles of the protein kinase C (PKC) and the tyrosine kinase (TK) signaling pathways in regulating capacitative calcium entry (CCE) in human pulmonary artery smooth muscle cells (PASMCs) and investigated the effects of intravenous anesthetics (midazolam, propofol
Doan-Trung Luu et al.
The Plant journal : for cell and molecular biology, 69(5), 894-905 (2011-11-05)
The constitutive cycling of plant plasma membrane (PM) proteins is an essential component of their function and regulation under resting or stress conditions. Transgenic Arabidopsis plants that express GFP fusions with AtPIP1;2 and AtPIP2;1, two prototypic PM aquaporins, were used
Gennadii Petrovich Gusev et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 180(3), 385-391 (2009-11-26)
Recently (Agalakova and Gusev in J Comp Physiol 179:443-450, 2009), we demonstrated that the activity of K-Cl cotransport (KCC) in frog red blood cells is inhibited under stimulation of protein kinase C (PKC) with phorbol ester PMA (12-myristate-13-acetate). Present work
Thanos Ghelis et al.
Plant physiology, 148(3), 1668-1680 (2008-09-05)
Protein tyrosine (Tyr) phosphorylation plays a central role in many signaling pathways leading to cell growth and differentiation in animals. Tyr phosphorylated proteins have been detected in higher plants, and the roles of protein Tyr phosphatases and protein Tyr kinases
Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
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