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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous glycerol solution
物種活性
rat, mouse, human
技術
microarray: suitable
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer199/pSer202)
基因資訊
human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
一般說明
Tau(τ),别名MAPT(微管相关蛋白tau),由位于人染色体17q21.3上的基因编码。高度表达于神经元细胞,在轴突中浓度最高。
Tau蛋白属微管相关磷蛋白(MAP),主要在中枢神经系统神经元中表达。在微管蛋白聚合中发挥重要作用,促进微管装配和稳定。tau蛋白的生物活性取决于其磷酸化程度。抗-磷酸化Tau(pSer199/202)抗体可用于微阵列和蛋白质印迹分析(western blotting)。还可用于免疫印迹分析。兔抗-磷酸化Tau (pSer199/202)抗体与人Tau (pSer199/202)(45-68 kD)特异性反应。
Tau蛋白属微管相关磷蛋白(MAP),主要在中枢神经系统神经元中表达。在微管蛋白聚合中发挥重要作用,促进微管装配和稳定。tau蛋白的生物活性取决于其磷酸化程度。抗-磷酸化Tau(pSer199/202)抗体可用于微阵列和蛋白质印迹分析(western blotting)。还可用于免疫印迹分析。兔抗-磷酸化Tau(pSer199/202)抗体与人Tau (pSer199/202)(45-68 kD)特异性反应。
免疫原
化学合成人tau蛋白含丝氨酸199和丝氨酸202区域来源的磷酸肽。
應用
兔生产的抗-磷酸化Tau(pSer199/202)抗体已用于:
- 免疫细胞化学
- 免疫组织化学
- 蛋白质印迹(western blot)
抗-磷酸化Tau (pSer199/202)抗体(用含0.3% Triton X-100和0.5% BSA的PBS1:1000稀释)可用于通过免疫细胞化学法鉴定蛋白聚集体。还可作为一抗(1: 3000稀释)用于免疫组织化学分析。
生化/生理作用
Tau(τ)在微管结构的组装和维持中起着至关重要的作用。tau(τ)缺失会导致发育迟缓和学习困难。其基因表达与阿尔茨海默症(AD)的发展有关。τ基因变异会提高罹患散发性tau蛋白病(sporadic tauopathies)、进行性核上性麻痹(PSP)和皮质基底节变性的风险。
外觀
溶于100 μl 杜氏磷酸盐缓冲液(不含Mg2+和Ca2+),pH 7.3,含50%甘油、1.0 mg/ml BSA(IgG,无蛋白酶)和0.05%叠氮化钠。本品的抗体量足够进行10次免疫印迹分析。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
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訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
320.0 °F - closed cup
閃點(°C)
160 °C - closed cup
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