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T3146

Sigma-Aldrich

三甲丙咪嗪标准液 马来酸盐

≥98% (TLC), powder

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About This Item

经验公式（希尔记法）:
C20H26N2 · C4H4O4
CAS号:
521-78-8
分子量:
410.51
EC號碼:
208-318-3
MDL號碼:
MFCD00082376
分類程式碼代碼:
12352116
PubChem物質ID:
24278731
NACRES:
NA.77

化驗

≥98% (TLC)

形狀

powder

顏色

white to off-white

溶解度

chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow

起源

Sanofi Aventis

儲存溫度

2-8°C

SMILES 字串

OC(=O)\C=C\C(O)=O.CC(CN(C)C)CN1c2ccccc2CCc3ccccc13

InChI

1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI 密鑰

YDGHCKHAXOUQOS-WLHGVMLRSA-N

基因資訊

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

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應用

Trimipramine maleate has been used to develop chiral separation methods using capillary electrophoresis4.

生化／生理作用

Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake.

準備報告

Trimipramine maleate is soluble in chloroform at 50 mg/ml to yield a clear, colorless to faint yellow solution.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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盐酸阿米替林 盐酸盐 ≥98% (TLC), powder

Sigma-Aldrich

A8404

盐酸阿米替林 盐酸盐

Chiral separation in non-aqueous media by capillary electrophoresis using the ion-pair principle.
Bjornsdottir, I., et al.
Journal of Chromatography A, 745(1), 37-44 (1996)
G Chouinard et al.
Cellular and molecular neurobiology, 19(4), 533-552 (1999-06-24)
1. The benzodiazepines are among the most frequently prescribed of all drugs and have been used for their anxiolytic, anticonvulsant, and sedative/hypnotic properties. Since absorption rates, volumes of distribution, and elimination rates differ greatly among the benzodiazepine derivatives, each benzodiazepine
F Plenge-Tellechea et al.
Archives of biochemistry and biophysics, 370(1), 119-125 (1999-09-25)
Tricyclic antidepressants are moderately potent inhibitors of the plasma membrane Ca(2+)-ATPase activity measured in erythrocyte ghosts. For the calmodulin-activated activity, half-maximal inhibition was observed in the presence of 0.25 mM clomipramine. Desipramine, imipramine, and trimipramine show half-maximal inhibition in the
J M Langosch et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(3), 209-212 (1998-08-26)
Trimipramine has been classified as an atypical tricyclic antidepressant, because only weak inhibitory effects on serotonin and/or noradrenaline reuptake have been found. Since some antidepressive drugs (e.g. imipramine) and other agents used in the treatment of affective disorders (e.g. carbamazepine)
Diansong Zhou et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(5), 863-870 (2010-02-06)
The role of human UDP glucuronosyltransferase (UGT) 2B10 in the N-glucuronidation of a number of tricyclic antidepressants was investigated and compared with that of UGT1A4 in both the Sf9 expressed system and human liver microsomes. The apparent K(m) (S(50)) values
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Chromatograms

application for HPLC

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