T2580

Trapoxin A

≥98% (HPLC), from Helicoma ambiens

• 别名: Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl), RF 1023A
• 经验公式（希尔记法）: C₃₄H₄₂N₄O₆
• CAS号: 133155-89-2
• 分子量: 602.72
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 生物来源: Helicoma ambiens
• 质量水平: 200
• 方案: ≥98% (HPLC)
• 表单: solid
• 溶解性: DMSO: soluble 0.9-1.10 mg/ml, clear, colorless to faintly yellow (may be further diluted 20 fold in H₂O); chloroform: soluble; methanol: soluble
• 运输: dry ice
• 储存温度: −20°C
• SMILES字符串: N21[C@H](CCCC2)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C1=O)Cc5ccccc5)Cc4ccccc4)CCCCCC(=O)[C@H]3OC3
• InChI: 1S/C34H42N4O6/c39-29(30-22-44-30)18-9-3-8-16-25-31(40)36-26(20-23-12-4-1-5-13-23)32(41)37-27(21-24-14-6-2-7-15-24)34(43)38-19-11-10-17-28(38)33(42)35-25/h1-2,4-7,12-15,25-28,30H,3,8-11,16-22H2,(H,35,42)(H,36,40)(H,37,41)/t25-,26-,27-,28+,30-/m0/s1
• InChI key: GXVXXETYXSPSOA-UFEOFEBPSA-N

说明

应用

Trapoxin A has been used:

• to study its effects on the inhibition of histone deacetylase 11 (HDAC11)[1]
• to study its effects on the inhibition of HDAC3 in human cell lines[2]
• to study its effects on the inhibition of HDAC6 in rat pyramidal neurons[3]

生化/生理作用

Trapoxin A is a cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor. It increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin A irreversibly inhibites HDAC activity in crude cell lysates, and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.

Trapoxin is a cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor.

特点和优势

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制备说明

Trapoxin A is soluble in DMSO at a concentration ranging from 0.9-1.10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in chloroform and methanol.

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H301
• 预防措施声明: P301 + P310
• 危险分类: Acute Tox. 3 Oral
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable