T2455

T3MG

• 别名: (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• 经验公式（希尔记法）: C₆H₁₁NO₄
• CAS号: 63088-04-0
• 分子量: 161.16
• MDL號碼: MFCD09836097
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826708
• NACRES: NA.77

属性

• 形狀: powder
• 顏色: white to off-white
• 溶解度: H₂O: >1.5 mg/dL
• 適合性: suitable for TLC (single spot)
• 儲存溫度: room temp
• SMILES 字串: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
• InChI 密鑰: FHJNAFIJPFGZRI-WVZVXSGGSA-N

说明

生化／生理作用

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

特點和優勢

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable