This product has not been tested for cell culture use. We offered Testosterone for cell culture, now discontinued, and for it our 1998 Sigma Cell Culture advised to dissolve 1 mg in 2.0 mL absolute ethanol, gently swirl to dissolve, then add 48 mL sterile medium to prepare 20 ug/ml stock solution. Working range: 20-300 ng/ml.
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生物源
synthetic (organic)
品質等級
無菌
non-sterile
化驗
≥98%
形狀
powder
藥物控制
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
溶解度
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml
absolute ethanol: soluble 0.5 mg/ml
chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow
H2O: insoluble
dioxane: soluble
methanol: soluble
methyl oleate: slightly soluble
vegetable oils: soluble
運輸包裝
ambient
儲存溫度
room temp
SMILES 字串
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
InChI
1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
InChI 密鑰
MUMGGOZAMZWBJJ-DYKIIFRCSA-N
基因資訊
human ... AR(367) , EBP(10682) , ESR1(2099) , PGR(5241) , SERPINA6(866) , SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208) , Esr1(24890) , Nr3c1(24413) , Nr3c2(25672) , Pgr(25154)
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生化／生理作用
睾丸分泌的睾酮在目标组织中转变为双氢睾酮，介导睾酮的多种生物作用。雄激素诱导胚胎发生和青春期的男性表型发育。
特點和優勢
该化合物是ADME Tox研究推荐产品。点击此处 ，查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
準備報告
睾丸激素以 100 mg/ml 的浓度溶于氯仿中，得到透明、无色至微弱的黄色溶液。它也可溶于甲醇、无水乙醇（0.5 mg/ml）、45％（w/v）2-羟丙基-b-环糊精水溶液（18.2 mg/ml）、植物油和二恶烷。微溶于油酸甲酯，不溶于水。
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Chikwendu Ibebunjo et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E327-E340 (2010-11-04)
Declines in skeletal muscle size and strength, often seen with chronic wasting diseases, prolonged or high-dose glucocorticoid therapy, and the natural aging process in mammals, are usually associated with reduced physical activity and testosterone levels. However, it is not clear
Anne T M Konkle et al.
Endocrinology, 152(1), 223-235 (2010-11-12)
The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex
David J Handelsman
The Journal of clinical endocrinology and metabolism, 91(5), 1646-1653 (2006-02-16)
The objective of the study was to review the rationale underlying the banning of human chorionic gonadotropin (hCG) and estrogen blockers (antiestrogens, specific estrogen receptor modulators, aromatase inhibitors) in sports for male and female athletes in the light of gender
Y Zimmerman et al.
Human reproduction update, 20(1), 76-105 (2013-10-02)
BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many
Frances S Chen et al.
Social cognitive and affective neuroscience, 10(6), 797-800 (2014-09-07)
Physical size and strength are associated with dominance and threat. The current study tested (i) whether men's evaluations of male strangers would be negatively influenced by cues indicating physical formidability, and (ii) whether these evaluations would be influenced by oxytocin
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How could I dissolve Product T1500, Testosterone for cell culture use?
1 answer-
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It is possible to sterile filter a solution of Product T1500, Testosterone?
1 answer-
A solution of testosterone cannot be sterile filtered, since the compound will stick to the filter paper, according to Sigma cell culture scientists' experience.
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What can I use to prepare a solution of Product T1500, Testosterone?
1 answer-
The product is soluble in absolute ethanol (0.5 mg/ml), It is also soluble in vegetable oils, soluble in dioxan and slightly soluble in methyl oleate.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How long can I store a solution of Product T1500, Testosterone?
1 answer-
We have not determined the solution stability of this product. As a guideline, please note the stability of product no. T5411, Testosterone solution 1.0 mg/mL, which is stable for 3 years at 2-8 C.
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What is the method of production for Product T1500, Testosterone?
1 answer-
This information is listed on the product's Certificate of Origin, which is lot-specific and, thus, subject to change. Enter the lot number of interest into the Certificate of Origin search box on the product page to find this information.
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