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product name
颗粒蛋白原小鼠, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)
生物源
mouse
重組細胞
expressed in HEK 293 cells
共軛
untagged
化驗
>95% (SDS-PAGE)
形狀
lyophilized
分子量
~65 kDa by SDS-PAGE
包裝
pkg of 10 μg
雜質
<0.1 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Grn(14824)
一般說明
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
外觀
Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.
重構
Reconstitute with 100 μL deionized water.
其他說明
Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury
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