SRP3135
p16-INK-4a TAT
recombinant, expressed in E. coli, lyophilized, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for mammalian cell culture
别名:
CDK4I, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, Multiple tumor suppressor 1, p16-INK4, p16INK4A
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所有图片(1)
About This Item
分類程式碼代碼:
12352202
NACRES:
NA.32
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product name
p16-INK-4a TAT human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
生物源
human
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
18 kDa
包裝
pkg of 25 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... CDKN2A(1029)
一般說明
Cyclin dependent kinase inhibitor 2A (CDKN2A) also known as p16-INK-4a, belongs to the Ink4 (inhibitor of CDK4) family of CDK inhibitors. It is encoded by the gene mapped to human chromosome 9p21 within the INK4a/ alternate reading frame (ARF) locus. Human P16-INK4A is localized in both nucleus and cytoplasm, and its expression increases with ageing in skin and kidney tissues.
生化／生理作用
Cyclin dependent kinase inhibitor 2A (CDKN2A), also known as p16-INK-4a, arrests cell cycle progression by inhibiting S-phase and promotes apoptosis. The encoded protein has anti-proliferative biological activity, and is implicated in the retinoblastoma (Rb) protein pathway. p16-INK-4a acts as a tumor suppressor and plays a vital role in ageing and cellular senescence. Increased expression of this protein might lead to various types of high grade cancers. p16-INK-4a also facilitates cell invasion and angiogenesis. Bronchial lavage P16INK4A promoter methylation might function as a potential biomarker for diagnosis of lung cancer.
序列
EPAAGSSMEP SADWLATAAA RGRVEEVRAL LEAGALPNAP NSYGRRPIQV MMMGSARVAE LLLLHGAEPN CADPATLTRP VHDAAREGFL DTLVVLHRAG ARLDVRDAWG RLPVDLAEEL GHRDVARYLR AAAGGTRGSN HARIDAAEGP SDIPDGYGR KKRRQRRR
外觀
Lyophilized with no additives.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing.
Lucchinett E
Anesthesiology (2012)
p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.
Oncogene (2011)
Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma.
Koenig A
Veterinary Pathology (2002)
Jinsuke Nishino et al.
Cell, 135(2), 227-239 (2008-10-30)
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16(Ink4a). We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural
A Okamoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(23), 11045-11049 (1994-11-08)
Cell cycle arrest at the G1 checkpoint allows completion of critical macromolecular events prior to S phase. Regulators of the G1 checkpoint include an inhibitor of cyclin-dependent kinase, p16INK4; two tumor-suppressor proteins, p53 and RB (the product of the retinoblastoma-susceptibility
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