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生化/生理作用
Broad-spectrum antibiotic with activity against both gram-positive and gram-negative bacteria
Enterocin is a bacteriostatic polyketide antibiotic unrelated to the polypeptide enterocin bacteriocins. It has broad-spectrum antibiotic activity against both gram-positive and gram-negative bacteria. Enterocin has also been shown to have inhibitory activity against β-amyloid protein (Aβ1-42) fibrillation and moderate cytotoxicity against HeLa and HepG2 cancer cell lines.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Exploring Natural Product Artifacts: The Polyketide Enterocin Warms to a Ballet of Isomers
Organic Letters, 22(12), 4828-4832 (2020)
Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin
Journal of Natural Products, 78(3), 539-542 (2015)
Dong-Bo Xu et al.
Applied microbiology and biotechnology, 99(14), 5825-5832 (2015-04-22)
The type II polyketide synthase (PKS) natural product enterocin (1) was isolated from a mangrove-derived novel species Streptomyces qinglanensis 172205 guided by genome sequence, and its putative biosynthetic gene cluster was revealed. Its natural analogues 5-deoxyenterocin (2) and wailupemycin A-C
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