跳转至内容
Merck
所有图片(1)

文件

C6830

Sigma-Aldrich

抗菌肽A

≥97% (HPLC), powder

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C184H313N53O46
CAS号:
80451-04-3
分子量:
4003.78
MDL號碼:
MFCD00130752
分類程式碼代碼:
12352202
NACRES:
NA.32

品質等級

200

化驗

≥97% (HPLC)

形狀

powder

抗生素活性譜

fungi
viruses

作用方式

cell membrane | interferes

儲存溫度

−20°C

InChI

1S/C184H313N53O46/c1-27-98(16)145(182(282)235-149(102(20)31-5)181(281)218-115(59-39-46-76-187)159(259)206-103(21)152(252)205-92-138(246)237-82-52-65-130(237)173(273)208-106(24)154(254)228-143(96(12)13)176(276)209-107(25)155(255)229-144(97(14)15)177(277)231-142(95(10)11)175(275)204-89-135(243)211-121(66-70-131(193)239)160(260)207-105(23)156(256)236-150(108(26)238)183(283)221-123(68-72-133(195)241)168(268)232-146(99(17)28-2)178(278)210-104(22)153(253)213-114(151(197)251)58-38-45-75-186)227-137(245)91-202-158(258)129(87-140(249)250)226-163(263)120(64-51-81-200-184(198)199)219-179(279)148(101(19)30-4)234-172(272)128(86-134(196)242)225-164(264)122(67-71-132(194)240)212-136(244)90-203-174(274)141(94(8)9)230-166(266)118(62-42-49-79-190)215-165(265)124(69-73-139(247)248)220-180(280)147(100(18)29-3)233-167(267)119(63-43-50-80-191)214-161(261)116(60-40-47-77-188)216-170(270)126(84-109-53-33-32-34-54-109)224-169(269)125(83-93(6)7)223-162(262)117(61-41-48-78-189)217-171(271)127(222-157(257)112(192)56-37-44-74-185)85-110-88-201-113-57-36-35-55-111(110)113/h32-36,53-55,57,88,93-108,112,114-130,141-150,201,238H,27-31,37-52,56,58-87,89-92,185-192H2,1-26H3,(H2,193,239)(H2,194,240)(H2,195,241)(H2,196,242)(H2,197,251)(H,202,258)(H,203,274)(H,204,275)(H,205,252)(H,206,259)(H,207,260)(H,208,273)(H,209,276)(H,210,278)(H,211,243)(H,212,244)(H,213,253)(H,214,261)(H,215,265)(H,216,270)(H,217,271)(H,218,281)(H,219,279)(H,220,280)(H,221,283)(H,222,257)(H,223,262)(H,224,269)(H,225,264)(H,226,263)(H,227,245)(H,228,254)(H,229,255)(H,230,266)(H,231,277)(H,232,268)(H,233,267)(H,234,272)(H,235,282)(H,236,256)(H,247,248)(H,249,250)(H4,198,199,200)/t98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108+,112-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-/m0/s1

InChI 密鑰

HCQPHKMLKXOJSR-IRCPFGJUSA-N

正在寻找类似产品? 访问 产品对比指南

Amino Acid Sequence

Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2

一般說明

天蚕素A属于天蚕素类，由L构象的37个氨基酸残基组成。结构上，该肽具有一个C端的疏水α-螺旋结构和两亲性的N端。天蚕素A是线性的，具有阳离子属性。

應用

天蚕素A已作为一种抗菌肽（AMP）被用于：
  • 检测其对乳腺癌（MDA-MB-231）和人间皮瘤（M14K）细胞系的细胞毒性作用
  • 在针对大肠杆菌的超灵敏发射扩散测定中用于检测大蜡螟蛋白24和apolipophorin III的作用
  • 在针对光杆状菌变种的灵敏度测定中用于检测最小抑制浓度（MIC）

生化／生理作用

天蚕素A可与细胞膜发生相互作用，使其对电解质具有渗透性。因此，天蚕素A在肝细胞癌和淋巴瘤中有助于细胞溶解并最终导致细胞死亡。在转基因水稻中的这种合成型天蚕素A具有抗细菌和真菌病原体的作用。
最初在飞蛾（刻克罗普斯蚕蛾）中鉴定出的抗菌肽随后在猪肠中也被鉴定出来。

其他說明

从0.1％TFA水溶液中冻干

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Shin Yong Park et al.
Developmental and comparative immunology, 29(1), 43-51 (2004-08-25)
Two hemolymph proteins were isolated from the wax moth, Galleria mellonella, larvae by a two-step procedure consisting of acid extraction and reversed phase (RP)-HPLC. One was an apolipophorin III (apoLp-III) previously characterized as a lipopolysaccharide (LPS) binding protein in the
Sichen Shao et al.
Cell, 147(7), 1576-1588 (2011-12-27)
Metazoans secrete an extensive array of small proteins essential for intercellular communication, defense, and physiologic regulation. Their synthesis takes mere seconds, leaving minimal time for recognition by the machinery for cotranslational protein translocation into the ER. The pathway taken by
Xiuqing Wang et al.
Experimental biology and medicine (Maywood, N.J.), 237(3), 312-317 (2012-03-02)
The hybrid peptide CA(1-7)-M(2-12) gene was designed according to the N-terminal 1-7 amino acid sequence of the antimicrobial peptide cecropin A (CA) and the N-terminal 2-12 amino acid sequence of maganin (M) and synthesized using Pichia pastoris preferred codons. The
Scott Matthews et al.
Parasites & vectors, 4, 77-77 (2011-05-17)
Paratransgenesis is an approach to reducing arthropod vector competence using genetically modified symbionts. When applied to control of Chagas disease, the symbiont bacterium Rhodococcus rhodnii, resident in the gut lumen of the triatomine vector Rhodnius prolixus (Hemiptera: Reduviidae), is transformed
José María Cerón et al.
Peptides, 31(8), 1494-1503 (2010-05-25)
Most antimicrobial peptides have been shown to have antitumoral activity. Cecropin A, a linear 37-residue antimicrobial polypeptide produced by the cecropia moth, has exhibited cytotoxicity in various human cancer cell lines and inhibitory effects on tumor growth. In this study
查看所有相关文献

商品

Antimicrobial Peptides

Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

Antimicrobial Peptides

Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

Antimicrobial Peptides

Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

抗菌肽

由于细菌耐药性和新出现的传染病成为人类的潜在威胁，核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。

查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门