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Compound 18 is an agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) that inhibit mosquito attraction to humans and other hosts. Compound 18 suppresses biting and blood-feeding on a live host. Also, It (MPO-IN-28) is a potent myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Laura B Duvall et al.
Cell, 176(4), 687-701 (2019-02-09)
Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling
Jalal Soubhye et al.
Journal of medicinal chemistry, 60(15), 6563-6586 (2017-07-04)
The heme enzyme myeloperoxidase (MPO) participates in innate immune defense mechanism through formation of microbicidal reactive oxidants. However, evidence has emerged that MPO-derived oxidants contribute to propagation of inflammatory diseases. Because of the deleterious effects of circulating MPO, there is
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