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Merck

SML2561

Sigma-Aldrich

ML162

≥98% (HPLC)

别名:

α-[(2-氯乙酰基)(3-氯-4-甲氧基苯基)氨基]-N-(2-苯乙基)-2-噻吩乙酰胺, 2-氯-N-(3-氯-4-甲氧基苯基)-N-(2-氧代-2-(苯乙基氨基)-1-(噻吩-2-基)乙基)乙酰胺, BRD-5421, BRD5421, CID 3689413, ML 162, ML-162, 分子库162

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About This Item

经验公式(希尔记法):
C23H22Cl2N2O3S
分子量:
477.40
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to very dark brown

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

生化/生理作用

ML162是一种小分子,可通过共价抑制细胞磷脂谷胱甘肽过氧化物酶(GPx-4;GPx4;GSHPx-4;PHGPx;SNGPx;snPHGPx)诱导铁死亡。癌症培养物中的合成致死性研究确定了诸如HRas(G12V)表达和富马酸水合酶(FH)缺失对ML162敏感性的影响因子(在BJeLR-HRas(G12V)&UOK262-FH-/-培养物中IC50分别为25 nM & 35 nM)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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