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Merck
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SML2114

Sigma-Aldrich

ZD7155 hydrochloride

≥97% (HPLC)

别名:

5,7-Diethyl-3,4-dihydro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride, ZD 7155

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About This Item

经验公式（希尔记法）:
C26H26N6O · HCl
CAS号:
146709-78-6
分子量:
474.99
MDL號碼:
MFCD00921888
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥97% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 2 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl

InChI

1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H

InChI 密鑰

NAGGAAHTUXEGFG-UHFFFAOYSA-N

生化／生理作用

ZD7155 is a potent selective Angiotensin II AT1 antagonist. In one study ZD 7155 was found to be longer-acting and approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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I L Junggren et al.
The Journal of pharmacy and pharmacology, 48(8), 829-833 (1996-08-01)
Binding experiments show that ZD 7155 is a potent angiotensin II type 1 receptor antagonist. In this study this novel substance was studied in normotensive and hypertensive rats. The relative potency and duration of the antihypertensive effects of ZD 7155
Signal Transduction and Targeted Therapy
Aung Than, Shaohai Xu, Ru Li, MelvinKhee-Shing Leow, Lei Sun and Peng Chen
Nature Chemical Biology, 2 (2017)
Haitao Zhang et al.
Nature, 544(7650), 327-332 (2017-04-06)
The angiotensin II receptors AT

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