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化驗
≥98% (HPLC)
形狀
powder
顏色
faint green to dark gray
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O
生化／生理作用
ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Xiang Li et al.
Microbiology (Reading, England), 170(6) (2024-06-25)
Bacterial infection is a dynamic process resulting in a heterogenous population of infected and uninfected cells. These cells respond differently based on their bacterial load and duration of infection. In the case of infection of macrophages with Crohn's disease (CD)
Tarsis F Brust et al.
Science signaling, 10(467) (2017-02-23)
Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that inhibitors of AC1 may be useful for treating pain and opioid dependence.
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