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Merck
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主要文件

SML1538

Sigma-Aldrich

NMDI14

≥97% (HPLC)

别名:

2-{[（6,7-二甲基-3-氧代-1,2,3,4-四氢-2-喹喔啉基）乙酰基]氨基} -4,5-二甲基-3-噻吩甲酸乙酯, 4,5-二甲基-2-[[2-（1,2,3,4-四氢-6,7-二甲基-3-氧代-2-喹喔啉基）乙酰基]氨基]-3-噻吩甲酸乙酯

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About This Item

经验公式（希尔记法）:
C21H25N3O4S
CAS号:
307519-88-6
分子量:
415.51
分類程式碼代碼:
12352200
NACRES:
NA.77
价格与库存信息目前不能提供

品質等級

100

化驗

≥97% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 0.2 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O

InChI 密鑰

QRLPSNLBUMVXBL-UHFFFAOYSA-N

應用

NMDI14作为mRNA无义介导降解(NMD)抑制剂的应用：
  • 研究其对分化心肌细胞的影响[1]
  • 研究其对斑马鱼pdzk1基因敲除胚胎的影响[2]
  • 分析其对结直肠癌细胞凋亡的影响[3]

生化／生理作用

NMDI14 是一种有效的无意义介导 RNA 衰变（NMD）抑制剂。 NMDI14 靶向 SMG7 蛋白的口袋，并破坏 SMG7-UPF1 相互作用。 NMDI14 可恢复具有提前终止密码子（PTC）突变的 p53 的细胞中的全长 p53 蛋白活性。
有效的无意义介导 RNA 衰变（NMD）抑制剂

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000368406
0000368405
0000368405
0000368406
0000355891

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Michael Bordonaro et al.
Journal of Cancer, 10(2), 287-292 (2019-02-06)
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD)
Greg H P Ngo et al.
Nature communications, 12(1), 3849-3849 (2021-06-24)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
Jiaheng Xie et al.
Investigative ophthalmology & visual science, 62(3), 29-29 (2021-03-23)
The human PDZK1 gene is located in a genomic susceptibility region for neurodevelopmental disorders. A genome-wide association study identified links between PDZK1 polymorphisms and altered visual contrast sensitivity, an endophenotype for schizophrenia and autism spectrum disorder. The PDZK1 protein is

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