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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
O=C1NC2=CC(C(F)(F)F)=CC=C2[C@@]1(C3=CC(Cl)=CC=C3OC)F
InChI
1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChI 密鑰
ULYONBAOIMCNEH-HNNXBMFYSA-N
基因資訊
human ... KCNMA1(3778) , KCNQ2(3785) , KCNQ3(3786) , KCNQ4(9132) , KCNQ5(56479)
應用
BMS 204352已被用于药物管理中。
生化/生理作用
BMS 204352是一种钾离子通道调节剂。BMS 204352最初是作为大电导体,钙激活(Maxi-K,KCa1.1,BK)钾离子通道,的有效开启剂,其也可充当Kv7(KCNQ)通道的正调节剂。
BMS 204352(MaxiPost [(3S)-(+)-(5-氯-2-甲氧基苯基)-1,3-二氢-3-氟-6-(三氟甲基)-2H-吲哚-2-酮)]已被用于治疗缺血性中风。它也可以相同的效力充当KNCQ4(类KQT的亚家族,成员4)和KCNQ5(类KQT的亚家族,成员5)的激活剂。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Cephalalgia : an international journal of headache, 40(11), 1145-1154 (2020-08-28)
Preclinical data implicate large conductance calcium-activated potassium (BKCa) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BKCa channels would cause headache and vascular effects
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.
Orphanet Journal of Rare Diseases, 9(1), 124-124 (2014)
A small molecule activator of KCNQ2 and KCNQ4 channels.
Probe Reports from the NIH Molecular Libraries Program (2013)
METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST IN HUMANS.
Drug Metabolism and Disposition, 33(1), 83-93 (2004)
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
PLoS Genetics, 14(1), e1007165-e1007165 (2018)
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