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Merck
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文件

SML0711

Sigma-Aldrich

RS504393

≥98% (HPLC)

别名:

6-甲基-1′-[2-（5-甲基-2-苯基-4-恶唑基）乙基]-螺 [4H-3,1-苯并恶嗪-4,4′-哌啶 ]-2 (1H)-酮, RS-504393

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About This Item

经验公式（希尔记法）:
C25H27N3O3
CAS号:
300816-15-3
分子量:
417.50
分類程式碼代碼:
51111800
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 1 mg/mL, clear (warmed)

儲存溫度

2-8°C

InChI

1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

InChI 密鑰

ODNICNWASXKNNQ-UHFFFAOYSA-N

應用

RS504393 已用于质谱分析。

生化／生理作用

RS504393 是一种高选择性 CCR2 趋化因子受体拮抗剂。RS504393 抑制肾脏 MCP-1 趋化和缺血再灌注损伤。
RS504393 有助于提高吗啡和丁丙诺啡在神经性大鼠中的镇痛效力。RS504393 具有阻断慢性压迫损伤 (CCI) 诱导的 IL-1 (白细胞介素 1) β、IL-18 (白细胞介素 18)、IL-6 (白细胞介素 6) 和诱导型一氧化氮合酶 (iNOS) 等前感受性因子上调的能力。

特點和優勢

《受体分类和信号转导》手册的 趋化因子受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats
Kwiatkowski K, et al.
Journal of Neuroimmune Pharmacology, 12(3), 402-419 (2017)
Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis
Winter C, et al.
Cell Metabolism (2018)
Bradley W Richmond et al.
Mucosal immunology, 14(2), 431-442 (2020-09-25)
Although activation of adaptive immunity is a common pathological feature of chronic obstructive pulmonary disease (COPD), particularly during later stages of the disease, the underlying mechanisms are poorly understood. In small airways of COPD patients, we found that localized disruption
Maira Licia Foresti et al.
Epilepsy & behavior : E&B, 102, 106695-106695 (2019-12-01)
Neuroinflammation role on epileptogenesis has been the subject of increasing interest. Many studies showed elevation in cytokines and chemokines expression following seizures, such as, CCL2 protein (C-C motif ligand 2 chemokine) and its specific receptor, CCR2. In addition, recent studies

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