SML0674

雷莫司琼 盐酸盐

≥98% (HPLC)

• 别名: (R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060
• 经验公式（希尔记法）: C₁₇H₁₇N₃O · HCl
• CAS号: 132907-72-3
• 分子量: 315.80
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]/D -36 to -46°, c = 1 in methanol
• 储存条件: desiccated
• 颜色: white to beige
• 溶解性: H₂O: 20 mg/mL, clear
• 储存温度: −20°C
• SMILES字符串: Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C
• InChI: 1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
• InChI key: XIXYTCLDXQRHJO-RFVHGSKJSA-N

说明

生化/生理作用

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.

Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302
• 预防措施声明: P264 - P270 - P301 + P312 - P501
• 危险分类: Acute Tox. 4 Oral
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable