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Merck
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文件

SML0314

Sigma-Aldrich

CGP77675

≥98% (HPLC)

别名:

1-(2-{4-[4-氨基-5-(3-甲氧基苯基)-7H-吡咯并[2,3-d]嘧啶-7-基]苯基}乙基)哌啶-4-醇, 1-(4-(4-氨基-5-(3-甲氧基苯基)-7H-吡咯并[2,3-d]嘧啶-7-基)苯乙基)哌啶-4-醇, CGP 77675, CGP-77675

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About This Item

经验公式（希尔记法）:
C26H29N5O2
CAS号:
234772-64-6
分子量:
443.54
MDL號碼:
MFCD20039929
分類程式碼代碼:
12352200
PubChem物質ID:
329825319
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25

InChI

1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)

InChI 密鑰

WUPXZZWTHIZICK-UHFFFAOYSA-N

一般說明

CGP77675属于吡咯并嘧啶类抑制剂。

應用

CGP77675已用于生成小鼠扩增的潜能干细胞。

生化／生理作用

CGP77675 是一种有效的 Src 激酶抑制剂。CGP77675对其他蛋白激酶具有选择性，包括Cdc2（>500倍），表皮生长因子（EGF）受体（7.5倍），血管内皮生长因子受体（>50倍），以及v-Abl（15倍）和粘着斑激酶（Fak）（>25倍）。
CGP77675可以预防白介素1β刺激的高钙血症。已知在卵巢切除的小鼠中，它能够预防骨质流失。 CGP77675以其在癌症治疗中的用途而闻名。

特點和優勢

这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.

Src Family Kinases Overview

Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.

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